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| Effect of Hog Millet Supplementation on Hepatic Steatosis and Insulin Resistance in Mice Fed a High-fat Diet |
| Mi-Young Park1, Hwan-Hee Jang1, Jin-Young Lee1, Young-Min Lee1, Jae-Hyun Kim1, Jae-Hak Park2, and Dong-Sik Park1 |
| 1Functional Food & Nutrition Division, National Academy of Agricultural Science, Rural Development Administration, Gyeonggi 441-707, Korea; 2College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea |
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Abstract
| The dietary intake of whole grains is known to reduce the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. In our previous study, hog millet (HM, Panicum miliaceum L.) water extract showed the highest anti-lipogenic activity among nine cereal types in 3T3-L1 cells. In this study, the effect of hog millet water extract on hepatic steatosis and lipid metabolism in mice fed a high fat diet was investigated. Mice were fed a normal-fat diet (ND), high-fat diet (HFD) or HFD containing 1% or 2% (w/w) HM for 7 weeks. Body weight and food intake were monitored during the study period. Insulin resistance by homeostasis model assessment (HOMA-IR), fasting lipid profile, hepatic fatty acid metabolism-related gene expression determined, and intraperitoneal glucose tolerance test (IGTT) were performed at the study's end. The results indicated that 1% and 2% HM diets effectively decreased liver weights, blood TG and T-cholesterol levels (p<0.05), while the HDL-cholesterol level was increased (p<0.05) compared to HFD-induced steatotsis mice. Hepatic lipogenic-related gene (PPARα, L-FABP, and SCD1) expressions decreased, whereas lipolysis-related gene (CPT1) expression increased in animals fed the 2% PME diet (p<0.05). In addition, mice fed 1% or 2% HM diet had markedly decreased IGTT and HOMA-IR, compared to the those of the HFD-induced hepatic steatosis control group (p<0.05). These results indicated that HM inhibited hepatic lipid accumulation by regulating fatty acid metabolism, and suggested that HM is useful in the chemoprevention or treatment of high fat-induced hepatic steatosis and hepatic steatosis-related disorders including hyperlipidemia, glucose sensitivity, and insulin resistance. |
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| Key words : Panicum miliaceum L., hog millet, high fat diet, insulin resistance, steatotsis |
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| Journal of the Korean Society of Food Science and Nutrition 41(4), 501~509 (2012) |
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