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| Effect of Combined Extract of Safflower Seed with Herbs on Blood Glucose Level and Biochemical Parameters in Streptozotocin⁃induced Diabetic Rats |
| Kyung⁃Mi Yang1, Seung⁃Ryeul Shin1 and Joung⁃Hyeon Jang2 |
| 1Faculty of Herbal Food Cooking & Nutrition, Daegu Haany University, Gyeongsan 712-715, Korea; 2Dept. of Cosmetology, Chang-Shin College, Masan 630-749, Korea |
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Abstract
| The aim of the present study was to investigate the effect of combined extract of safflower seed with herbs on the improvement of blood glucose, lipid peroxides, lipids in the plasma and liver of strpetozotocin⁃induced diabetic rats. Rats in the experimental group were orally administered with combined extract of safflower seed (100 mg, 200 mg/kg B.W.) with herbs (Ophiopogon japonicus Ker⁃Gaqler, Glycyrrhiza uralensis Fisch, Mori Folium, Poria cocos, Rehmannia glutinosa, Eriobtrya japonica, Aralia continentalis Kitagawa, Zizyphus jujuba var, Cornus officinalis, Paeonia suffruticosa, Trichosanthes kirilowii Maxim and Schizandra chinensis Baill) for 4 weeks. Body weight gain and food efficiency ratio were significantly lower in diabetic groups than those of control group. These were no protective effect of the supplementation of combined extract of safflower seed with herbs. Concentration of blood glucose was significantly higher in the diabetic groups than those in the control group. Blood glucose concentration was remarkably lower supplementation of combined extract of safflower seed (200 mg/kg B.W.) with herbs. There was no significant difference of plasma lipid peroxides among experimental groups, while liver lipid peroxides of diabetic group was significantly higher in control group. But supplementation of combined extract of safflower seed with herbs was induced markedly lower in liver lipid peroxides in diabetic rats. Diabetic groups had markedly higher levels in triglycerides, LDL⁃cholesterol and atherogenic index, while had lower HDL⁃cholesterol level. Triglyceride levels of plasma and liver were significantly lower with combined extract of safflower seed with herbs. But total cholesterol, phospholipid and free fatty acid were no differing significantly among experimental groups. |
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| Key words : streptozotocin:safflower seed:herbs:blood glucose:lipid peroxide |
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| Journal of the Korean Society of Food Science and Nutrition 35(2), 150~157 (2006) |
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